Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
24 Citrate decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
26 Trimethylamine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
27 Trimethylamine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
28 Trimethylamine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
29 Choline decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
30 Glycerophosphocholine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
31 Glycerophosphocholine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
32 Glycerophosphocholine increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
33 Trimethylamine-N-Oxide increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
34 Scyllo-inositol increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
36 alpha- and beta-glucose decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
37 Glycine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
59 Deteriorarition of circadian rhytms 10090 Farajnia, et al 2012 — Suprachiasmatic Nucleus age 2 month 30 month — Aged mice have disrupted sleep hevaiour and weakened brain network activity in the SCN. Aged SCN neurons lack day-night rhythms in some membrane properties. There is an age-related reductions of certain potassium currents that are import to the neuron’s rhythmic firing. Behavioral and sleep-wake rhythms exhibit a strong fragmentation, starting at the age of 700 d. Aged mice are deficient in membrane properties and GABAergic postsynaptic current amplitude. Aging mice selectively loss circadian modulation of fast-delayed-rectifer and A-type K+ currents. In aged mice at the tissue level, the phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in anti-phase and a reduction in amplitude of the overall multiunit activity rhythm.
67 Bone loss 10090 — 13678781 bone age 42 week 104 week male In young mice the rapid growth is marked by substantial increase in bone size, mineral mass and mechanical properties. Maturation occurring between 12 and 42 weeks of age was characterized with the maintenance of bone mass and mechanical properties. From the peak levels, mice aged for 104 weeks exhibited decreased whole femur mass, percentage of mineralization diminished whole bone stiffness, energy to fracture and decreased cortical thickness. Periosteal perimeter and, consequently the cross-sectional moments of inertia continued to increase through 104 weeks, compensating for cortical thinning and increased brittleness due to decreased mineralization and stiffness. The shape of the mid-diaphysis became increasingly less elliptical in aged mice. After 52 weeks excessive endocortical resorption appeared, indicating a shift in normal mechanisms regulating bone shape and locating, suggestive of remodelling [13678781].
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
71 Telomere shortening 10090 — 22585399 — age — — — Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880].
73 p16 expression increases 10090 — — — age — — — p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
75 Metabolic and mitochondrial decline 10090 — 22585399 — age — — males/females 2 years old mice exhibit metabolic and mitochondrial decline [22585399].
87 LysoPC(16:1) decrease 10090 — 22661299 — — 3 months 12 momths — Plasma levels of LysoPC(16:1) decreases with age from 3 to 22 months [22661299].
90 Accumulation of DNA damage 10090 — — — age — — — DNA damage accumulates with age in mouse hematopoietic stem cells [32 in Lauri et al. 2012].
91 LysoPC(18:4) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of LysoPC(18:4) decrease from 3 to 22 months [22661299].
92 SM(d18:1/12:0) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of SM(d18:1/12:0) decreasefrom 3 to 22 months [22661299].
93 Tetracosahexaenoic acid decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of Tetracosahexaenoic acid decrease from 3 to 22 months [22661299].
94 7alpha-dihydroxy-4-cholesten-4-one decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of 7alpha-dihydroxy-4-cholesten-4-one decreases from 3 to 33 months [22661299].
99 Decreased body fat 10090 — — — Diet DR AL — Body fat decreases upon DR [6608731].

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