Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
108 Rgil induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Eno1 levels [Herbert et al. in press].
119 Rgi1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Rgi1 levels [Herbert et al. in press].
74 Reduced regenerative capacity — — — — — — — — Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
124 Reduced expression of autophagy genes 7227 — 18059160 neural age old young — The expression of several autophagy genes is reduced in neural tissues as a normal part of aging [18059160].
65 Protein expression variation increases 4932 Levy et al., 2012 — — age — — — Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
60 Protein aggregation 6239 — 22103665 whole body age 1 day 11 day hermaphrodites protein aggreation accumulate in aged animals. Hundrets of protein are enriched in an SDS-insoluble fraction in aged nematode adn alre largely absent from similiar protein fraction in young nematodes. Genes encoding proteins that become insoluble with age are enriched for modifiers of lifespan [22103665].
49 Progesterone declines 9606 — — — Age 70/35 year — male/female —
73 p16 expression increases 10090 — — — age — — — p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
120 Oye2 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Oye2 levels [Herbert et al. in press].
77 Osh6 downregulation — Gebre et al., unpublished — — age — — — Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].
76 OSH5 upregulation 4932 Gebre et al. unpublished — — age — — — OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
17 N-acetyl glycoprotein increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
18 N-acetyl glycoprotein increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
16 N-acetyl glycoprotein decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
41 Mitochondrial dysfunction increases 9606 Petersen et al., 2003 12750520 muscle Age — — — Aging is accompanied by an increase in mitochondrial dysfunction in muscle of humans [12750520].
20 Methionine increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
19 Methionine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
75 Metabolic and mitochondrial decline 10090 — 22585399 — age — — males/females 2 years old mice exhibit metabolic and mitochondrial decline [22585399].
130 Melatonin decreases — — 18212404 — age old young — Melatonin level decrease with age [reviewed in 18212404].
47 Melatonin declines 9606 — — — Age 70/35 year — male/female Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)).
122 Lysosomal cholesterol content decreases 10116 Fusheng Tang, personal communication — liver age young old — In rat liver cells, the content of cholesterol in the lysosomal membrane decreases with age in spite of the overall increase of total cellular sterols.
91 LysoPC(18:4) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of LysoPC(18:4) decrease from 3 to 22 months [22661299].
87 LysoPC(16:1) decrease 10090 — 22661299 — — 3 months 12 momths — Plasma levels of LysoPC(16:1) decreases with age from 3 to 22 months [22661299].
117 Lys9 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — High osmolarity upregulates Lys9 levels [Herbert et al. in press].
44 Luteneinzing hormone increases 9606 Jeff — — Age 40 year — male and female Luteneizing hormone increases dramatically and becomes much more bioactive after the age 40 in both mena nd women.

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