Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
106 Hxk1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Hxk1 levels [Herbert et al. in press].
105 Eno1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Eno1 levels [Herbert et al. in press].
104 Hsp12 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Hsp12 levels [Herbert et al. in press].
103 Decreased stem cell activity — — 20504968 — age — — — Advanced age is associated with decreased stem cell activity [20504968].
102 Increased fat synthesis and oxidation 10090 — — — diet DR AL — During DR there is an increased fat synthesis and oxidation [19887594].
101 Enhanced mitochondrial function 7227 Zid et al. 2009 19804760 — diet DR AL — Flies upon DR have enhanced mitochondrial function, which is mediated by enhanced mRNA translation of nuclear-encoded mitochondrial mRNAs in a d4E-BP dependent manner [19804760]
100 Increase in steady-state triglyceride content 7227 Katewa et al. 2012 — — diet DR (0.5% yeast extract) AL (5% yeast extract) female/male Flies on DR exhibit an increase in steady-state levels of triglyceride content [22768842].
99 Decreased body fat 10090 — — — Diet DR AL — Body fat decreases upon DR [6608731].
98 Shift in metabolism towards increasing fatty acid syntheses and breakdown 7227 Katewa et al. 2012 — muscle diet DR (0.5% yeast extract) AL (5% yeast extract) female/male Flies on DR shift their metabolism toward increasing fatty acid synthesis and breakdown, specifically in muscle tissues, which is required for varoius responses to DR [22768842].
97 Diminished cognitive skills 9606 — — — age — — — Cognitive skill such as learning and memory diminish with age [http://www.sciencedaily.com/releases/2012/06/120629211902.htm].
96 Loss of histone proteins from the genome 4932 — 20832724 — age — — — Normal aging is accompanied by a profound loss of histone proteins from the genome [20832724].
95 Ceramides increase — — — — age — — — Sphingosine-linked fatty acids like ceramides serve as "damage-associated molecular patterns" (DAMPs) are increased in aged tissue and cause inflammatory damage via activation of Nlrp3 inflammasome [Vandanmagsar et al. 2011; Youm et al. 2012].
94 7alpha-dihydroxy-4-cholesten-4-one decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of 7alpha-dihydroxy-4-cholesten-4-one decreases from 3 to 33 months [22661299].
93 Tetracosahexaenoic acid decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of Tetracosahexaenoic acid decrease from 3 to 22 months [22661299].
92 SM(d18:1/12:0) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of SM(d18:1/12:0) decreasefrom 3 to 22 months [22661299].
91 LysoPC(18:4) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of LysoPC(18:4) decrease from 3 to 22 months [22661299].
90 Accumulation of DNA damage 10090 — — — age — — — DNA damage accumulates with age in mouse hematopoietic stem cells [32 in Lauri et al. 2012].
89 Chromosomal anomalies 969 — — — age — — — Chromosomal anomalies (rearrangements and aneuploidies) during cell division increases with age in cultured lymphocytes and fibroblasts [30,31 in Lauri et al. 2012].
88 Structural chromosome variation 9606 — — — — — — — Acquired differences in structural chromosome variants between members of monozygoutic twin pairs (including mosaic anomalis) are observed in pairs of >55 years of age but not in younger [29 in Laurie et al. 2012].
87 LysoPC(16:1) decrease 10090 — 22661299 — — 3 months 12 momths — Plasma levels of LysoPC(16:1) decreases with age from 3 to 22 months [22661299].
86 Clonal mosicaism frequency increases 9505 Hunter et al. 2012 — blood — 50 79 female/male Detectable clonal mosaicism frequency in peripheral blood is low (<0.5 %) from birth until 50 years of age, after which it rapidley rises to 2-3% in the elderly. The frequency of mosic abnormalities increases with age, from 0.23% under 50 years to 1.91% between 75 and 79 years [Hunter et al. 2012].
85 Cell proliferation decreases 10116 — 11744049 — Diet — — — 24 month DR in rats inhibits cell proliferation in glandular stomach and liver tissue [11744049].
84 Cell proliferation increases 1016 11744049 — — Diet — — — 24 month DR in rats enhances cell proliferation in duodenum and forestomach mucosal tissue [11744049].
83 elt-3 expression increases 6239 — 17608836 — age — — — Expression of elt-3 increases during devleopment and aging [17608836].
82 elt-6 expression increases 6239 — 17608836 — age — — — Expression of elt-6 increases during devleopment and aging [17608836].

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