Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
---|---|---|---|---|---|---|---|---|---|---|
26 | Trimethylamine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
27 | Trimethylamine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
28 | Trimethylamine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
29 | Choline decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
30 | Glycerophosphocholine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
31 | Glycerophosphocholine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
32 | Glycerophosphocholine increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
33 | Trimethylamine-N-Oxide increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
34 | Scyllo-inositol increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
36 | alpha- and beta-glucose decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
37 | Glycine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
38 | HDL increases | 9606 | Fontana et al., 2004 | 15096581 | Plasma | Diet | Chronic DR | — | — | — |
39 | AMP/ATP increases | 6239 | Apfeld et al., 2004 | 15574588 | whole body | Age | 4 day | 18 day | Hemaphrodite | AMP/ATP ratio in living animals increases from <0.1 at day 4 of adulthood to 0.8 at day 18 (an age near the maximum lifespan of the population). Linear regression indicates a strong correlation between AMP/ATP ratio and life expectancy. |
40 | Accumulation of lipofuscin-like fluorescent pigment | 6239 | Apfeld et al., 2004 | 15574588 | intestine | Age | 1 day | 7 day | Hemaphrodite | A lipofuscin-like fluorescent pigment accumulates in an age-dependent manner in the intestine (Garigan et al., 2002; Herndon et al., 2002). It accumulates at a faster rate in aak-2 mutant, which have a shortened lifespan [15574588]. |
41 | Mitochondrial dysfunction increases | 9606 | Petersen et al., 2003 | 12750520 | muscle | Age | — | — | — | Aging is accompanied by an increase in mitochondrial dysfunction in muscle of humans [12750520]. |
43 | Follicle stimulating hormone increases | 9606 | Jeff | — | — | Age | 40 year | — | male and emale | Follicle stimulating hormone increases dramatically and becomes much more bioactive after the age of 40 in both men and women. |
44 | Luteneinzing hormone increases | 9606 | Jeff | — | — | Age | 40 year | — | male and female | Luteneizing hormone increases dramatically and becomes much more bioactive after the age 40 in both mena nd women. |
45 | human chorionic gonadotrophin increases | 9606 | Jeff | — | — | Age | 40 year | — | male and female | human chorionic gonadotrophin hCG increases in both men and women after age 40. |
46 | DHEA declines | 9606 | Jeff | — | — | — | 70 | — | male | — |
47 | Melatonin declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)). |
48 | Growth hormone declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | — |
49 | Progesterone declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | — |
50 | Vitamin D3 declines | 9606 | — | — | — | — | — | — | — | As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically. |
51 | DHEA increases | 9606 | Willcox et al., 2007 | 17986602 | serum | diet | Okinawa | — | — | Okinawa aged 65-plus have relatively high DHEA levels. |
52 | DHEA decreases | 9606 | Hinson and Raven, 1999 | 10495400 | serum | age | 25 year | 85 year | males/females | DHEAS (Dehydroepiandrosterone sulphate) is the most abundant circulating steroid secreted by adrenal glands. Duo to its position int the steroid cascade DHEA act like kind of âthe mother steroidâ (Regelson et al., 1994). DHEA reaches its highest levels at age 20-24. Its serum concentration declines with increasing age after 25 years and diminishes about 95% by 85 years. DHEA deficiency syndrome is a new term for old age [10495400]. |
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