Symbol: Sod2 Name: Superoxide dismutase 2 (Mn) Entrez gene ID: 36878 Ensembl gene ID: FBgn0010213 Species: Fly (Taxid: 7227) Functional description: Protects cells against oxygen toxicity; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. [UniProt] Observation: RNA interference of Sod2 results in increased oxidative stress and early-onset mortality in young adults [12456885]. Overexpression of Sod2 by 5-115% decreases lifespan by 4-5% without any compensatory changes in metablic rate, level of physical activity, or the levels of other antioxidants (Sod, Cat, and glutathione) [10545213]. Targeted overexpression of Sod2 in motor neurons alone extends lifespan by 30% [11113599]. Induced overexpression of Sod2 in adult animals extends lifespan up to 37% [12072463]. Overexpression of catalase in combination with SOD2 has no added benefit for lifespan [12072463]. Animals overexpressing SOD2 or catalase do not exhibit a decrease in metabolism as measured by oxgen consumption [12072463]. Sod2 overexpression results in a 20% increase in mean and maximum lifespan [18067683]. Interventions: Assays: Organismal Lifespan Mean: +20 Maximum: +20 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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