Symbol: Polg Name: Polymerase (DNA directed), gamma Entrez gene ID: 18975 Ensembl gene ID: ENSMUSG00000039176 Species: Mouse (Taxid: 10090) Functional description: polymerase (DNA directed), gamma; polymerase (DNA directed), gamma [Source:MGI Symbol;Acc:MGI:1196389] [Ensembl] Observation: Mice with a proof-reading-deficient version of Polg display an increased amount of mtDNA mutations (by 3 to 5-fold) and signs of premature ageing including a reduced lifespan, weight loss, reduced subcutaneous fat, alopecia, kyphosis, osteoporosis, anaemia, reduced fertility, and heart enlargement. Median lifespan of homozyous Polg mutant knock-in mice is 48 months [15164064]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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