Symbol: Sh Name: Shaker Entrez gene ID: 32780 Ensembl gene ID: FBgn0003380 Species: Fly (Taxid: 7227) Functional description: Voltage-dependent potassium channel involved in regulation of sleep need or efficiency. Mediates the voltage- dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium- selective channel through which potassium ions may pass in accordance with their electrochemical gradient. [UniProt] Observation: Genetic mutation in Sh decreases lifespan by accelerating the aging process. At 25 degree mean and maximum lifespan is reduced by 16 and 22%, while by 18 degree Celsius the reduction is 32 and 21% [8582611]. Interventions: Assays: Organismal Lifespan Mean: -16 to -32 Maximum: -21 to -22 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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