Symbol: his-2
Name: HIStone
Entrez gene ID: 180074
Ensembl gene ID: T10C6.13
Species: Worm
(Taxid: 6239)
Functional description:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [UniProt]
Observation:
his-2 RNAi in the adulthood extends the lifespan [New longevity regulators]
Interventions:
his-2 RNAi
Assays:
Organismal Lifespan
Classification:
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
HIST1H3A
(9606)
HIST1H3I
(9606)
HIST1H3G
(9606)
HIST1H3J
(9606)
HIST1H3F
(9606)
HIST1H3C
(9606)
HIST1H3B
(9606)
HIST1H3D
(9606)
HIST1H3E
(9606)
HIST1H3H
(9606)
LOC736427
(9598)
H3F3B
(9598)
HIST1H3A
(9598)
LOC608586
(9615)
LOC504599
(9913)
LOC619141
(9913)
Hist1h3c
(10090)
Hist1h3f
(10090)
Hist2h3c2-ps
(10090)
Hist2h3b
(10090)
Hist1h3b
(10090)
Hist1h3e
(10090)
Hist1h3d
(10090)
LOC680498
(10116)
LOC100329422
(7955)
zgc:158629
(7955)
LOC564732
(7955)
LOC100006146
(7955)
LOC100000930
(7955)
LOC100006182
(7955)
LOC570703
(7955)
LOC100004914
(7955)
LOC100001294
(7955)
LOC563243
(7955)
LOC100333965
(7955)
LOC560616
(7955)
LOC100001555
(7955)
LOC100329423
(7955)
zgc:173552
(7955)
LOC100335000
(7955)
LOC100149321
(7955)
LOC100334741
(7955)
LOC560090
(7955)
LOC561114
(7955)
LOC560897
(7955)
LOC100334933
(7955)
LOC100333750
(7955)
LOC100332949
(7955)
His3:CG33803
(7227)
His3:CG31613
(7227)
His3:CG33806
(7227)
His3:CG33809
(7227)
His3:CG33812
(7227)
His3:CG33815
(7227)
His3:CG33818
(7227)
His3:CG33821
(7227)
His3:CG33824
(7227)
His3:CG33827
(7227)
His3:CG33830
(7227)
His3:CG33833
(7227)
His3:CG33866
(7227)
His3:CG33836
(7227)
His3:CG33863
(7227)
His3:CG33839
(7227)
His3:CG33860
(7227)
His3:CG33842
(7227)
His3:CG33857
(7227)
His3:CG33845
(7227)
His3:CG33854
(7227)
His3:CG33848
(7227)
His3:CG33851
(7227)
AgaP_AGAP012559
(7165)
AgaP_AGAP003910
(7165)
AgaP_AGAP012573
(7165)
AgaP_AGAP005024
(7165)
AgaP_AGAP012572
(7165)
AgaP_AGAP005025
(7165)
his-25
(6239)
his-13
(6239)
his-42
(6239)
his-59
(6239)
his-45
(6239)
his-55
(6239)
his-63
(6239)
his-49
(6239)
his-9
(6239)
his-32
(6239)
his-2
(6239)
his-27
(6239)
his-17
(6239)
his-6
(6239)
AT5G65350
(3702)
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