Symbol: cit-1.2 Name: CyclIn T 1.2 Entrez gene ID: 176126 Ensembl gene ID: F44B9.3 Species: Worm (Taxid: 6239) Functional description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). [UniProt] Observation: RNA interference cit-1.2 decreases median lifespan by 27% in daf-2 mutants [18006689]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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