Symbol: Cdkn1a Name: Cyclin-dependent kinase inhibitor 1A Alias: p21 Entrez gene ID: 12575 Ensembl gene ID: ENSMUSG00000023067 Species: Mouse (Taxid: 10090) Functional description: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). [UniProt] Observation: Deletion of Cdkna1 (alias p21) prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres and improves the repopulation capacity and self-renewal of hematopoietic stem cells [17143283]. The p21(-/-) strains like the Cdkn1a(tmi/Tyj) exhibits enormous regenerative capacities as it closes ear holes similar to MRL mice [20231440; 21722344]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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