Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
    H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    S65C HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    rs1800629 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
    rs909253 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
    Ile119Val PCMT1 — 0.049 40 vs 40 — Ashkenazi Jewish Mean age 87.2 — — Candidate Region/Gene 10496068
    TNF haplotypes TNF — 0.01 60 vs 50 — Bulgarian Age range: 65-99 — −1031 C/C, −863 C/A, −857 C/C, −308 G/G, +489 G/G Candidate Region/Gene 21299522
    rs1044891 FOXO3A 1.17 0.14 298 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 113 — — Candidate Region/Gene 19489743
    rs2153960 FOXO3A 1.16 0.019 300 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 115 — — Candidate Region/Gene 19489743
    rs3778588 FOXO3A 1.22 0.023 301 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 116 — — Candidate Region/Gene 19489743
    rs9486902 FOXO3A 1.18 0.073 303 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 118 — — Candidate Region/Gene 19489743
    rs9486913 FOXO3A 1.18 0.053 304 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 119 — — Candidate Region/Gene 19489743
    FOXO3A, various FOXO3 1.67 0.0002 760 vs 1060 — Chinese 100+ — — Candidate Region/Gene 20884733
    rs1799945 HFE — 0.008 57 vs 60 — Italian 100-105 — — Candidate Region/Gene 12714263
    rs1800629 TNF — 1.0 174 vs 224 — Italian >100 — — Candidate Region/Gene 12676903
    rs9340799 ESR1 — 1.0 148 vs 414 — Polish mean age 101.1 — — Candidate Region/Gene 20599431
    rs1800629 TNF — 0.76 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    HLA DRB1*18 HLA-DRB1 — 0.0266 77 vs 299 — 100 — — Candidate Region/Gene 20426625
    rs5746098 SOD2 — 0.355 130 vs 135 — Jordanian Mean age 90.01 — — Candidate Region/Gene 20003469
    rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs9340799 ESR1 — 0.22 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs2227956 HSPA1L — 0.328 168 cases — Danish Mean age 92.8 +/- 0.4 — — Candidate Region/Gene 20388090
    rs2274776 FOXO3 0.95 0.536 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs1571631 FOXO3 0.99 0.872 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs6911407 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
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    • 25 of 102 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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