Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population.

Authors: Khabour OF; Abdelhalim ES; Abu-Wardeh A

Abstract: BACKGROUND: Aging in animals is associated with high body oxidative stress, which might affect susceptibility and onset of age-related diseases, and the subsequent life span. Therefore, genes that modulate oxidative stress might play a role in determining longevity. In this study, we investigated whether the gene pool relevant to the SOD2-9T/C and MTHFR 677C/T polymorphisms changes as the Jordanian population ages. METHODS: Polymorphisms were genotyped in 130 elderly subjects (57 females and 73 males, mean age: 90.01 years) and 135 young control subjects (67 females and 68 males, mean age: 33.43 years). RESULTS: No significant differences were found in the genotype and allele frequencies of examined SOD2 and MTHFR gene variants between the elderly group and young controls (P > 0.05), nor when each gender was considered separately (P > 0.05). CONCLUSION: SOD2-9T/C and MTHFR 677C/T gene polymorphisms do not seem to be important in Jordanian population for longevity phenotype.

Keywords: Adult; Aged; Aged, 80 and over; Arabs/*genetics/statistics & numerical data; Case-Control Studies; Cohort Studies; Female; Genotype; Humans; Jordan; Longevity/*genetics; Male; Methylenetetrahydrofolate Reductase (NADPH2)/*genetics; Middle Aged; Polymorphism, Single Nucleotide/*genetics; Superoxide Dismutase/*genetics; Young Adult
Journal: BMC geriatrics
Volume: 9
Pages: 57
Date: Dec. 17, 2009
PMID: 20003469
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Citation:

Khabour OF, Abdelhalim ES, Abu-Wardeh A (2009) Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population. BMC geriatrics 9: 57.


Longevity Variant Associations (p-value):
  • rs5746098 (0.355)
  • rs1801133 (0.727)

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