Authors: Ross OA; Curran MD; Rea IM; Hyland P; Duggan O; Barnett CR; Annett K; Patterson C; Barnett YA; Middleton D
Abstract: Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-alpha and G+252A TNF-beta), associated with increased TNF-alpha production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.
Keywords: Adult; Aged; Aged, 80 and over; Aging/genetics/immunology; Female; Gene Frequency; Genotype; Histocompatibility Testing; Humans; Linkage Disequilibrium; Longevity/*genetics/*immunology; Male; Middle Aged; Northern Ireland; *Polymorphism, Genetic; Tumor Necrosis Factor-alpha/*genetics|
Journal: Mechanisms of ageing and development Volume: 124 Issue: 4 Pages: 563-7 Date: April 26, 2003 PMID: 12714268 |
Ross OA, Curran MD, Rea IM, Hyland P, Duggan O, Barnett CR, Annett K, Patterson C, Barnett YA, Middleton D (2003) HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. Mechanisms of ageing and development 124: 563-7.
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