Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    DRD4 7R allele DRD4 3.5e-08 310 vs 2909 European mean age 95.2 years Candidate Region/Gene 23283341
    rs4936894 VWA5A 1.11 3.38e-07 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
    rs507879 CASP5 1.4e-05 510 vs 549 Russian 75–103 AG AA, GG Candidate Region/Gene 20434535
    rs4938180 IGSF4 1.91 2.16e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs10502005 MMP20 1.48 2.42e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs680109 GRIA4 2.52e-05 1364 American, British Age range 50-108; mean age at death 80.2 C A Genome-Wide Association Study 22445811
    rs7103504 CNTN5 4.39e-05 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs7952321 OR5AS1 4.68e-05 1364 American, British Age range 50-108; mean age at death 80.2 T G Genome-Wide Association Study 22445811
    rs651922 DCPS 1.19 4.75e-05 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    VNTR in intron 5 (DeltaEF1 site) SIRT3 8e-05 242 vs 703 Italian Median age 102 2b Candidate Region/Gene 15676284
    rs2073586 ABCC8 0.48 8.15e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
    rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish 100+ A Candidate Region/Gene 16602826
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old C A Candidate Region/Gene 22406557
    rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish mean age 98.2 A Candidate Region/Gene 16602826
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 C Candidate Region/Gene 22406557
    rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
    rs1470196 KIAA1377 1.33 0.000498694 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs4237774 OR56A1 1.18 0.000637699 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs2542052 APOC3 0.001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
    rs7127390 IGSF4 1.13 0.001091248 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs739401 CARS 0.00154 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
    rs216493 PLEKHA7 1.10 0.001543457 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) HRAS 1.13 0.002 234 vs 467 Italian centenarians a3 allele (see notes) Candidate Region/Gene 11943467
    rs4073591 DEAF1 0.002618 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
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    • 25 of 81 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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