Authors: Khabour OF; Barnawi JM
Abstract: Cytokines are crucial for the regulation of inflammation development in humans. Many studies have shown that variations in cytokine genes might play a role in determining human longevity. This study examined the changes in the gene pool relevant to the -308 G/A polymorphism in the promoter region of the proinflammatory cytokine tumour necrosis factor (TNF)-alpha gene and the -1082 G/A polymorphism in the promoter region of anti-inflammatory cytokine interleukin (IL)-10 gene with aging and survival selection occurs in the Jordanian population. IL-10 -1028 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years. No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05) while the IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05). Thus, IL-10 -1028 G/A polymorphism seems to play a role in the pathway to longevity in Jordanian men.Keywords: Adult; Aged, 80 and over; Alleles; Arabs/*genetics/statistics & numerical data; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Inflammation/genetics; Interleukin-10/*genetics/physiology; Jordan/epidemiology; Longevity/*genetics/immunology; Male; Polymorphism, Restriction Fragment Length; *Polymorphism, Single Nucleotide; Promoter Regions, Genetic/*genetics; Sampling Studies; Sex Factors; Tumor Necrosis Factor-alpha/*genetics/physiology
Journal: International journal of immunogenetics
Date: June 4, 2010
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Khabour OF, Barnawi JM (2010) Association of longevity with IL-10 -1082 G/A and TNF-alpha-308 G/A polymorphisms. International journal of immunogenetics 37: 293-8.