Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    −455 G/A FGB — 0.56 2224 — American, Caucasian 65+ — — Candidate Region/Gene 15939070
    rs9995651 SNCA — 0.98 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs8192678 PPARGC1A — 0.469 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs795602 MGST2 0.67 4.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs765850 APBB2 1.10 0.000259753 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs7656234 SLC4A4 1.16 0.000700593 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs750032 PPP3CA — 0.0029 653 (197 m, 456 f) vs non-mentioned 564 (92 m, 472 f) vs 564___(Franch Caucasians) American, Caucasian Mean 100,8 — — Genome-Wide Association Study 14615589
    rs6812745 SORCS2 1.21 0.000558765 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs61733139 MTTP — 0.32 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
    rs61733139 MTTP — 0.43 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
    rs4647992 NFKB1 1.81 0.000608192 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs3796661 SNCA — 0.59 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3775439 SNCA — 0.025 769 total (see notes) — Caucasian >90 (oldest age group) A — Candidate Region/Gene 22912757
    rs3775423 SNCA — 0.9 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3756063 SNCA — 0.54 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3736265 PPARGC1A — 0.509 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs358256 GBA3 1.12 0.001136273 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs356218 SNCA — 0.53 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2866164 MTP — 0.05 205 vs 288 — Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
    rs2866164 MTTP — 1.0 1651 vs 575 — Danish 92-93 — — Candidate Region/Gene 16015282
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs2866164 MTTP — 0.05 126 vs 288 — Ashkenazi Jewish median age = 97 CG/GG — Candidate Region/Gene 22496539
    rs2866164 MTP — 0.024 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 GG — Candidate Region/Gene 18034366
    rs2737033 SNCA — 0.27 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2737012 SNCA — 0.21 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
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    • 25 of 60 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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