Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    MTP -493G/T MTP 0.854 Chinese - 23273182
    rs2282679 GC 0.6 1038 vs 461 Dutch 59.5 years (offspring of nonagerians) Candidate Region/Gene 23128285
    −455 G/A FGB 0.56 2224 American, Caucasian 65+ Candidate Region/Gene 15939070
    rs2866164 MTP 0.05 205 vs 288 Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
    rs2069762 IL-2 1.43 0.096 168 vs 214 Italian Centenarians G T Candidate Region/Gene 16518704
    rs2866164 MTTP 1.0 1651 vs 575 Danish 92-93 Candidate Region/Gene 16015282
    11 different snps tested, not all given. MTTP 1.0 1398 vs 777 British 77.9 ± 0.2 Candidate Region/Gene 17339647
    Not specified IL2 0.05 470 vs 120 Italian, Bulgarian Age range: 65-99 Candidate Region/Gene 21299522
    rs1800591 MTTP 0.032 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.32 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs8192678 PPARGC1A 0.469 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs3736265 PPARGC1A 0.509 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    -330T/G IL2 1.43 0.096 168 vs 214 Italian >99 Candidate Region/Gene 16518704
    A-3826G (rs1800592) - C-3740A UCP1 0.81 0.014 236 vs 741 Italian >91 G-A Candidate Region/Gene 21827845
    rs2866164 MTTP 0.05 126 vs 288 Ashkenazi Jewish median age = 97 CG/GG Candidate Region/Gene 22496539
    rs10014396 SNCA 0.021 769 total (see notes) Caucasian >90 (oldest age group) C Candidate Region/Gene 22912757
    rs3775439 SNCA 0.025 769 total (see notes) Caucasian >90 (oldest age group) A Candidate Region/Gene 22912757
    rs356218 SNCA 0.53 769 total (see notes) Caucasian >90 (oldest age group) Candidate Region/Gene 22912757
    rs17180453 SNCA 0.63 769 total (see notes) Caucasian >90 (oldest age group) Candidate Region/Gene 22912757
    rs3775423 SNCA 0.9 769 total (see notes) Caucasian >90 (oldest age group) Candidate Region/Gene 22912757
    rs2736990 SNCA 0.31 769 total (see notes) Caucasian >90 (oldest age group) Candidate Region/Gene 22912757
    rs2572324 SNCA 0.41 769 total (see notes) Caucasian >90 (oldest age group) Candidate Region/Gene 22912757
    rs3796661 SNCA 0.59 769 total (see notes) Caucasian >90 (oldest age group) Candidate Region/Gene 22912757
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    • 25 of 60 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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