Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    MTP -493G/T MTP — 0.854 — — Chinese — — — - 23273182
    rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
    −455 G/A FGB — 0.56 2224 — American, Caucasian 65+ — — Candidate Region/Gene 15939070
    11 different snps tested, not all given. MTTP — 1.0 1398 vs 777 — British 77.9 ± 0.2 — — Candidate Region/Gene 17339647
    rs10937739 PPP2R2C — 0.00404 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs795602 MGST2 0.67 4.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2866164 MTTP — 1.0 1651 vs 575 — Danish 92-93 — — Candidate Region/Gene 16015282
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs10014396 SNCA — 0.021 769 total (see notes) — Caucasian >90 (oldest age group) C — Candidate Region/Gene 22912757
    rs3775439 SNCA — 0.025 769 total (see notes) — Caucasian >90 (oldest age group) A — Candidate Region/Gene 22912757
    rs356218 SNCA — 0.53 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs17180453 SNCA — 0.63 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3775423 SNCA — 0.9 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2736990 SNCA — 0.31 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2572324 SNCA — 0.41 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3796661 SNCA — 0.59 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2737033 SNCA — 0.27 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs9995651 SNCA — 0.98 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2583959 SNCA — 0.21 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2737012 SNCA — 0.21 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs1372519 SNCA — 0.19 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs3756063 SNCA — 0.54 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs1372520 SNCA — 0.22 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619361 SNCA — 0.26 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619362 SNCA — 0.27 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
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    • 25 of 60 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue