Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    apoE haplotypes — — 0.0042 3924 — American 5-70 Apo e4 — Candidate Region/Gene 21332925
    rs11235972 UCP3 — 0.029 908 vs 708 — Danish 93 A — Candidate Region/Gene 22743239
    rs1685354 UCP3 — 0.762 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
    rs3781907 UCP3 — 0.05 908 vs 708 — Danish 93 G — Candidate Region/Gene 22743239
    rs647126 UCP3 — 0.447 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
    LPA isoform LPA — 0.05 84 (cases) vs 517 — Japanese 80+ Lp(a)F, Lp(a)B — Candidate Region/Gene 11269751
    82133 G>A — — 0.0189 33 vs 39 — Japanese 90+ A — Candidate Region/Gene 15820493
    5-HTTLPR SLC6A4 — 0.03 15 male, 53 female centenarians (cases) — Australian, Caucasian 101.0 ± 0.2 L/L (only for males) — Candidate Region/Gene 22985157
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
    rs1937 TFAM — 0.003 107 vs 284 — Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
    SV-6 CLU — 1.0 49 vs 27 vs 20 — Greek, Italian 99–107 — — Candidate Region/Gene 16804001
    I550V Human Indy homolog — 0.0551 17 vs 1321 — African American, Asian, Caucasian, Hispanic 90-99 A G Candidate Region/Gene 14499494
    rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
    rs1800896 IL10 — 0.031 119 vs 118 — Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    KIR2DS3 KIR2DS3 — 0.02 93 vs 100 89 vs 89 Irish 80-97 — — Candidate Region/Gene 15288696
    KIR2DL5 KIR2DL5 — 0.03 93 vs 100 89 vs 89 Irish 80-97 — — Candidate Region/Gene 15288696
    CHIT1 24-bp duplication CHIT1 — 0.05 129 vs 129 29 versus 129 Tunisian, Greek, Italian Mean age 97.6 Absence of duplication Presence of duplication Candidate Region/Gene 19881466
    GSTT1 deletion GSTT1 — 0.03 94 vs 418 — Italian Mean age 100.2 Not homozygous for d Homozygous for delet Candidate Region/Gene 11162685
    G1691A F5 — 0.004 432 vs 184 — Polish Minimum age 95 A G Candidate Region/Gene 20720309
    rs708272 CETP — 0.068 523 vs 498 — Chinese Mean age 93.4 — — Candidate Region/Gene 22336474
    rs1043618 HSP70-A1A — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
    rs6457452 HSP70-A1B — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
    1082, 819, 592 IL-10 — 0.05 17 vs 105 — Bulgarian Mean age 78.9 ACC/ATA GCC/ACC Candidate Region/Gene 15050300
    rs1799752 ACE — 0.016 12 vs 190 vs 105 — Greek 99-111 D I Candidate Region/Gene 23389097

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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