Mitochondriogenesis genes and extreme longevity.

Authors: Santiago C; Garatachea N; Yvert T; Rodríguez-Romo G; Santos-Lozano A; Fiuza-Luces C; Lucia A

Abstract: Genes of the proliferator-activated receptor delta (PPARD)-peroxisome proliferator-activated receptor gamma coactivator 1alpha (PPARGC1A, also termed PGC1-alpha)-nuclear respiratory factor (NRF)-mitochondrial transcription Factor A (TFAM) mitochondriogenesis pathway can influence health/disease phenotypes, yet their association with extreme longevity is not known. We studied the association of five common polymorphisms in genes of this pathway (rs2267668, rs8192678, rs6949152, rs12594956, rs1937) and extreme longevity using a case (107 centenarians)-control (284 young adults) design. We found no between-group differences in allele/genotype frequencies, except for CC genotype in rs1937 (p=0.003), with no representation in controls (0%), versus 2.8% in centenarians (2 men, 1 woman). In summary, the studied genetic variants of the PPARD-PPARGC1A-NRF-TFAM pathway were not associated with extreme longevity, yet a marginal association could exist for rs1937.

Journal: Rejuvenation research
Volume: 16
Issue: 1
Pages: 67-73
Date: Nov. 29, 2012
PMID: 23186209
Select reference article to upload


Citation:

Santiago C, Garatachea N, Yvert T, Rodríguez-Romo G, Santos-Lozano A, Fiuza-Luces C, Lucia A (2013) Mitochondriogenesis genes and extreme longevity. Rejuvenation research 16: 67-73.


Longevity Variant Associations (p-value):
  • rs2267668
  • rs8192678
  • rs12594956
  • rs6949152
  • rs1937 (0.003)

  • Update (Admin) | Auto-Update

    Comment on This Data Unit