Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (153)   Locus (2)   Haplotype (31)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
    APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
    Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
    rs2542052 APOC3 — 0.0001 213 old vs 216 offspring vs 258 controls — Ashkenazi Jewish 100+ A — Candidate Region/Gene 16602826
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
    rs1800896 IL10 — 0.031 119 vs 118 — Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    GSTT1 deletion GSTT1 — 0.03 94 vs 418 — Italian Mean age 100.2 Not homozygous for d Homozygous for delet Candidate Region/Gene 11162685
    G1691A F5 — 0.004 432 vs 184 — Polish Minimum age 95 A G Candidate Region/Gene 20720309
    rs1799752 ACE — 0.016 12 vs 190 vs 105 — Greek 99-111 D I Candidate Region/Gene 23389097
    rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
    T-455C APOC3 — 0.005 183 vs 110 — Russian 70-106 T C Candidate Region/Gene 11193221
    ACE D/I ACE — 0.02 689 — Danish Minimum age 73 II DI, DD Candidate Region/Gene 12547486
    rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
    ADA genotypes ADA — 0.003 62 vs 64 vs143 vs 272 — Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
    rs507879 CASP5 — 1.4e-05 510 vs 549 — Russian 75–103 AG AA, GG Candidate Region/Gene 20434535
    rs1800629 TNF — 0.019 747 — Italian 19-110 A G Candidate Region/Gene 18511747
    rs1800795 IL-6 — 0.018 285 — Finn 90-95 C G Candidate Region/Gene 15664628
    rs1800871 IL-10 — 0.0026 500 — Japanese 56.7 years; range, 19–100 years TC TT Candidate Region/Gene 16424284
    Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
    G477T SIRT3 — 0.0272 801 — Italian 120 subject aged 100 or older GT TT Candidate Region/Gene 14580859
    HFE C282Y HFE — 7.2e-07 35 vs 106 — 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
    rs1800896 IL10 — 0.019 174 vs 227 — Italian >100 — GG Candidate Region/Gene 12676903
    rs2866164 MTP — 0.05 205 vs 288 — Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
    APOE polymorphism APOE — 0.0001 291 vs 589 — Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    • Page 1 of 14
    • 25 of 344 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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