Authors: Okayama N; Hamanaka Y; Suehiro Y; Hasui Y; Nakamura J; Hinoda Y
Abstract: Increased inflammatory activity is known to accompany aging. Single nucleotide polymorphisms of inflammatory mediator genes might therefore affect the aging process. Relation of eight SNPs (tumor necrosis factor-alpha [TNF-alpha] -1031 T/C, interleukin-10 [IL-10] -819 T/C, IL-1beta -511 C/T, IL-6 -634 C/G, IL-18 -607 A/C, transforming growth factor-beta [TGF-beta] +869 C/T, matrix metalloproteinase-1 [MMP-1] -1607 1G/2G, and MMP-3 -1171 5A/6A) with age or gender was evaluated in 500 Japanese persons (mean age: 56.7 years old, range: 19-100) by the chi-square test. There was a significant association of IL-10 -819 T/C with age (p =.0026). The association remained significant after multivariate logistic regression analysis (odds ratio for an age interval for 1 year, 1.009; 95% CI, 1.002-1.016). Furthermore, the genotype distribution of IL-10 -819 T/C was completely consistent with that of -592 A/C. These data suggest that IL-10 -819 T/C and -592 A/C may be a promising candidate for an aging-related gene in a Japanese population.
Keywords: Adult; Aged; Aged, 80 and over; Aging/*genetics; Cytokines/genetics; Female; Humans; Interleukin-10/*genetics; Male; Matrix Metalloproteinase 3/genetics; Middle Aged; *Polymorphism, Single Nucleotide|
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 60 Issue: 12 Pages: 1525-9 Date: Jan. 21, 2006 PMID: 16424284 |
Okayama N, Hamanaka Y, Suehiro Y, Hasui Y, Nakamura J, Hinoda Y (2005) Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging. The journals of gerontology. Series A, Biological sciences and medical sciences 60: 1525-9.
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