Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (39)   No Age Effect (43)  
  • Study type: + -
    ‑ (1)   Candidate Region/Gene (53)   Meta‑Analysis (1)   Complete Mitochondrial Genome (1)   Mitochondrial Haplogroup (31)  
  • Variant type: + -
    Haplotype « 
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    7600A,4833G,14569A,10400T mtDNA — 0.153 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    9824C,10400T mtDNA — 0.955 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    12811C,9824C,10400T mtDNA — 0.587 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    7196A,10400T mtDNA — 0.847 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    8684T,7196A,10400T mtDNA — 0.457 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    13263G,7196A,10400T mtDNA — 0.485 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    4491A,3705G,10400T mtDNA — 0.027 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    10646A,10400T mtDNA — 0.753 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    5417A,10873T mtDNA — 0.018 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    12358G,5417A,10873T mtDNA — 0.058 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    1736G,10873T mtDNA — 0.288 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    3970T,12705C,10873T mtDNA — 0.147 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    12406A,3970T,12705C,10873T mtDNA — 0.304 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    9bp-deletion,10873T mtDNA — 0.311 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    8584A,9bp-deletion,10873T mtDNA — 0.117 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    15235G,8584A,9bp-deletion,10873T mtDNA — 0.086 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    15662G,8584A,9bp-deletion,10873T mtDNA — 0.357 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    5465C,9bp-deletion,10873T mtDNA — 0.105 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    13590A,9bp-deletion,10873T mtDNA — 0.43 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1042718-rs1042719 ADRB2 0.63 1.86e-05 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G-C A-C Candidate Region/Gene 23020224
    rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
    rs1061581-rs1043618-rs2227956 — 4.51 0.016 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases — Danish Mean age 92.8 +/- 0.4 — G-C-T (haplotype) Candidate Region/Gene 20388090
    rs1800796-(−373(A)n(T)m)-rs1800795 IL6 — 0.07 1710 total — Danish 47-100 G-(−373(A)8(T)12)-C non G-(−373(A)8(T)12)-C haplotypes Candidate Region/Gene 15130757
    mtDNA haplogroups mtDNA — 0.027 138 — Spaniard Minimum age 85 non-J J Mitochondrial Haplogroup 18931934

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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