Modest implication of interleukin-6 promoter polymorphisms in longevity.

Authors: Christiansen L; Bathum L; Andersen-Ranberg K; Jeune B; Christensen K

Abstract: The multifunctional interleukin-6 has been suggested to contribute to a chronic low-grade inflammatory status, thereby conferring susceptibility to age-related pathological conditions as well as functional decline and increased mortality. Several polymorphisms have been identified in the interleukin-6 promoter, but investigation of the effect of these on interleukin-6 levels and disease susceptibility have led to contradictory results. This study investigates the significance of the three single-point polymorphisms (-597G/A, -572G/C and -174G/C) and the AT-stretch polymorphism (-373(A)n(T)m) in ageing, by comparison of the frequency of each single polymorphism separately as well as the entire promoter haplotype in a total of 1710 Danish subjects ranging in age from 47 to 100 years. We found a modest, but significant, increase in the frequency of interleukin-6 -174GG homozygotes with age suggesting that this genotype is advantageous for longevity.

Keywords: Adolescent; Adult; Aged; Aged, 80 and over; Aging/*genetics/immunology/pathology; Child; Child, Preschool; Female; Humans; Infant; Inflammation/genetics/immunology/mortality/pathology; Interleukin-6/*genetics/immunology; Longevity/*genetics/immunology; Male; Middle Aged; Polymorphism, Single Nucleotide/genetics/immunology; Promoter Regions, Genetic/*genetics/immunology
Journal: Mechanisms of ageing and development
Volume: 125
Issue: 5
Pages: 391-5
Date: May 8, 2004
PMID: 15130757
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Citation:

Christiansen L, Bathum L, Andersen-Ranberg K, Jeune B, Christensen K (2004) Modest implication of interleukin-6 promoter polymorphisms in longevity. Mechanisms of ageing and development 125: 391-5.


Longevity Variant Associations (p-value):
  • rs1800796
  • rs1800795 (0.01)
  • −373(A)n(T)m
  • rs1800796-(−373(A)n(T)m)-rs1800795 (0.07)

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