Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4746720 SIRT1 2.10 0.0001 223 vs 277 — Chinese Average age 93 CC, TT CT Candidate Region/Gene 23450480
    rs12778366 SIRT1 0.69 0.025 1390 — Dutch 36 to 79 — — Candidate Region/Gene 23505545
    MNS16A TERT 0.75 0.019 200 vs 539 — Italian 88+ MNS16A*L — Candidate Region/Gene 23562826
    rs2297518 NOS2 — 0.066 321 vs 442 — Italian 89-107 — — Candidate Region/Gene 23572278
    rs1879417 — — 0.018 321 vs 442 — Italian 89-107 — — Candidate Region/Gene 23572278
    rs2701858, rs9486902 — 3.23 0.0001 1088 — Danish 92+ — — Candidate Region/Gene 23607278
    rs1799752 ACE 1.25 0.032 1803 vs 10484 — Multiethnic Centenarian — DD Meta-Analysis 23623925
    rs1799752 ACE 1.16 0.001 1803 vs 10484 — Multiethnic Centenarian — D Meta-Analysis 23623925
    rs4673 — 1.48 0.022 — — Russian — C T Candidate Region/Gene 23755540
    rs4980329 SIRT3 — 0.02 357 — Italian 70+ — A Candidate Region/Gene 23839864
    rs11555236 SIRT3 — 0.03 357 — Italian 70+ — T Candidate Region/Gene 23839864
    e4 APOE — 0.04 376 vs 376 — Canadian 85+ e4 — Candidate Region/Gene 24126160
    rs1333049 CDKN2B-AS1 — 0.088 152 vs 343 — Spanish 100 C G Candidate Region/Gene 24163049
    rs9536314 KL 1.14 0.05 2913 vs 2206 — Multiethnic — — — Meta-Analysis 24164579
    rs2075650 APOE 0.53 4.44e-16 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1525501 — 0.72 4.94e-06 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs3803833 — 0.77 2.72e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1016013 — 1.21 2.87e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs216148 CSF1R 0.75 6.36e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1867102 C9orf3 1.20 7.28e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1822590 — 1.21 7.57e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs4918255 SORCS1 1.21 8.81e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1456669 — 0.78 9.89e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs915179 LMNA 1.19 0.0001 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs2738679 WWOX 1.60 6.85e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    • Page 1 of 42
    • 25 of 1027 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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