Authors: Zheĭkova TV; Golubenko MV; Buĭkin SV; Botkina OIu; Tsimbaliuk IV; Maksimov VN; Voevoda MI; Puzyrev
Abstract: Life span depends on many factors, including the level of reactive oxygen species, like superoxide radical. Superoxide radical is produced from oxygen in the course of the oxidation of NADPH to NADP+. The process is catalyzed by NADPH oxidase. In this study, genotype and allele distributions of the C242T polymorphism in the CYBA gene, which encodes the alpha subunit ofNADPH oxidase (p22phox), were examined in the sample of long livers and in the population sample of the city of Tomsk. Statistically significantly higher frequency of T allele among female long livers (34.62%), compared to the females from Russian population (26.32%) was demonstrated (chi2 = 5.226; p = 0.022; OR = 1.48). Thus, the T allele is associated with a high life expectancy in females from the Russian population. No such association was observed for males from the same population.Keywords: Adult; Alleles; Female; Genotype; Humans; Longevity/*genetics; Male; NADPH Oxidase/*genetics; Polymorphism, Single Nucleotide; Reactive Oxygen Species/metabolism; Risk Factors; Russia; Sex Characteristics; Superoxides
Date: June 13, 2013
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Zheĭkova TV, Golubenko MV, Buĭkin SV, Botkina OIu, Tsimbaliuk IV, Maksimov VN, Voevoda MI, Puzyrev (2013) [Association between 242C > T polymorphism of NADPH oxidase p22phox gene (CYBA) and longevity in Russian population]. Genetika 49: 410-4.