Authors: Huang J; Sun L; Liu M; Zhou L; Lv ZP; Hu CY; Huang ZZ; Zheng CG; Zhou L; Yang Z
Abstract: OBJECTIVE: To assess the association between SIRT1 gene polymorphisms and the longevity phenomena in Yongfu region of Guangxi. In this case-control study, 500 individuals from Yongfu region of Guangxi were recruited. The subjects were divided into a longevity group (n=223, average age=93.17 U+00B1 3.08 yr) and a healthy control group (n=277, average age=46.92 U+00B1 17.12 yr). Polymerase chain reaction-high resolution melting curve (PCR-HRM) and DNA sequencing were used to determine the allelic and genotypic frequencies of rs3758391, rs3740051, rs2273773, rs4746720 and rs10997870 polymorphisms of SIRT1 gene in the two groups. The association between above polymorphisms and longevity was assessed. RESULTS: In the longevity group, CT genotype of the rs4746720 locus was significantly more common than CC and TT genotypes (P=0.000, OR=2.098, 95%CI:1.412-4.117). However, no significant difference was found in the allelic and genotypic frequencies of rs3758391, rs3740051 and rs2273773 between the two groups. CONCLUSION: There is an association between rs4746720 of SIRT1 gene and longevity in Yongfu region of Guangxi.Keywords: Adult; Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group/*genetics; Base Sequence; Case-Control Studies; China; Female; Gene Frequency; Gene Order; Genetic Association Studies; Genotype; Humans; Longevity/*genetics; Male; Middle Aged; *Polymorphism, Single Nucleotide; Sirtuin 1/*genetics; Young Adult
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Date: March 2, 2013
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Huang J, Sun L, Liu M, Zhou L, Lv ZP, Hu CY, Huang ZZ, Zheng CG, Zhou L, Yang Z (2013) [Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 30: 55-9.