Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (84)   No Age Effect (161)  
  • Study type: + -
    ‑ (14)   Candidate Region/Gene (180)   Genome‑Wide Association Study (67)   Mitochondrial Haplogroup (1)  
  • Variant type: + -
    SNP (157)   Haplotype (23)   Other (1)   STR (1)   Deletion (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs969845 — 5.87 7.22e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs6166 FSHR 4.21 0.036 114 vs 173 — Italian >/=90 Asn Ser Candidate Region/Gene 22985084
    rs422858 AGTR1 3.57 0.007 173 vs 376 — Italian 99-106 (mean 100.9±1.7) AG CC Candidate Region/Gene 22569962
    rs275653 AGTR1 3.57 0.007 173 vs 376 598 vs 422 Italian 99-106 (mean 100.9±1.7) A G Candidate Region/Gene 22569962
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K — Candidate Region/Gene 23354683
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 — Italian 100+ — REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    APOE polymorphism APOE 3.26 0.001 64 vs 1344 — Italian 100+ e4 e2 Candidate Region/Gene 16960022
    G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination — 3.19 0.0006 208 vs 514 — Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
    rs7583529 CFLAR 3.15 6.45e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7873259 ANKRD19 3.14 1.18e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1800896 IL-10 3.00 0.0003 142 vs 153 — Italian Mean age 67 AA GG Candidate Region/Gene 15466015
    rs1584547 — 2.96 8.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs731287 — 2.51 9.88e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2070325 LPLUNC4 2.42 5.98e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs10923806 — 2.30 7.24e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs8052394 MT1a 2.16 0.0002 151 vs 100 — Italian Mean age 91.4 +/- 4.1 — A Candidate Region/Gene 16955215
    rs964403 SUMF1 2.07 4.91e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs3864051 SUMF1 2.07 5.49e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4505466 SH3BP4 2.06 8.31e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1805097 IRS2 2.03 0.0003 144 vs 418 — Italian 85-100 years old non-AA AA Candidate Region/Gene 19887537
    rs4777170 — 2.00 4.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2277472 MAMDC1 1.95 7.93e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs73598374 ADA 1.94 0.036 261 vs 144 — Italian 66-88 G*/G* A*+ Candidate Region/Gene 21865054
    • Page 1 of 11
    • 25 of 263 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue