Authors: Seripa D; Franceschi M; Matera MG; Panza F; Kehoe PG; Gravina C; Orsitto G; Solfrizzi V; Di Minno G; Dallapiccola B; Pilotto A
Abstract: We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/epsilon2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.Keywords: Aged; Aged, 80 and over; Aging/*genetics; Apolipoproteins E/*genetics; Female; Genetics, Population; Genotype; Humans; Hybrid Vigor; Italy; Logistic Models; Longevity/*genetics; Male; Middle Aged; Peptidyl-Dipeptidase A/*genetics; *Polymorphism, Genetic; Sex Factors
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences
Date: Sept. 9, 2006
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Seripa D, Franceschi M, Matera MG, Panza F, Kehoe PG, Gravina C, Orsitto G, Solfrizzi V, Di Minno G, Dallapiccola B, Pilotto A (2006) Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. The journals of gerontology. Series A, Biological sciences and medical sciences 61: 918-23.