Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1801133 MTHFR — 0.06 564 vs. 374 — French mean age 100.71 TT CT, CC Candidate Region/Gene 9106548
    rs1800871 IL-10 — 0.0026 500 — Japanese 56.7 years; range, 19–100 years TC TT Candidate Region/Gene 16424284
    rs1801133 MTHFR 6.00 0.014 224 vs 441 — Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
    rs3753645 SHC1 1.28 0.64 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 T — Candidate Region/Gene 14530863
    rs3753644 SHC1 1.28 0.64 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 T — Candidate Region/Gene 14530863
    M/T235 AGT 0.67 0.53 187 vs 201 — Danish centenarians T — Candidate Region/Gene 11602206
    Met410Val SHC1 — 0.192 730 563 Human 85+ Met — Candidate Region/Gene 15036421
    rs3215173 SHC1 1.60 0.15 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 G/- — Candidate Region/Gene 14530863
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian — G,C T Candidate Region/Gene 19249341
    rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
    rs12050077 TSHR 1.68 0.0001 232 vs 163 — Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs1800896 IL10 — 0.031 119 vs 118 — Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    rs3211994 NTLH1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs3818361 CR1 — 0.563 1364 — American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
    rs1800896 IL10 3.10 0.0003 142 vs 153 — Mean age 67 AA GG Candidate Region/Gene 15466015
    rs1800896 IL-10 3.00 0.0003 142 vs 153 — Italian Mean age 67 AA GG Candidate Region/Gene 15466015
    G1691A F5 — 0.004 432 vs 184 — Polish Minimum age 95 A G Candidate Region/Gene 20720309
    --1082G-->A IL10 — 0.0001 109 (oldest old men) vs 263 (healthy controls) — Italian >95 A — Candidate Region/Gene 15466015
    - F5 — 0.045 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 A — Candidate Region/Gene 15621215
    Not specified REN — 0.029 157 vs 218 — Italian Centenarians 11 — Candidate Region/Gene 15105583
    rs1801274 FCGR2A — 0.05 408 vs 446 vs 454 — German 100–110/ mean101.3 (SNP is His/Arg) — Candidate Region/Gene 16893392
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs2476601 PTPN22 — 0.663 225 vs 278 — Italian Mean age 93 — — Candidate Region/Gene 21113673
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 — Italian 100+ — REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
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    • 25 of 58 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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