APOB

Symbol: APOB
Name: apolipoprotein B (including Ag(x) antigen)
Entrez gene ID: 338
Ensembl gene ID: ENSG00000084674
Species: Human (Taxid: 9606)


Observation:

A sample of 143 centenarians and a control sample of 158 individuals were examined for polymorphism in APOB restriction fragment length (RFLP) (XbaI2488 and EcoRI4154) and variable number of tandem repeat (VNTR) (3'APOB-VNTR) polymorphisms. Neither the XbaI-RFLP nor the EcoRI-RFLP was able to discriminate between centenarians and controls, while the 3'APOB-VNTR multiallelic system revealed significant differences between the samples: the frequency of alleles with fewer than 35 repeats was lower in centenarians than in controls [9050915].apoB was found to be associated with longevity [17393087].APOB was found to be associated with longevity [15028112]. APOB was found to be associated with longevity [17393087]. APOB was not found to be associated with longevity [17393087]. APOB was found to be associated with longevity [9050915]. APOB was not found to be associated with longevity [11592926]. APOB was not found to be associated with longevity [8018664]. APOB was not found to be associated with longevity [9050915].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • VNTR (Variable Number of Tandem Repeats) 0.003 [9050915]
  • rs693 None [8018664]
  • XbaI 0.03 [17393087]
  • SI000565Q 0.001 [17393087]
  • rs11279109 None [17393087]
  • SI000565Q 0.0005 [17393087]
  • SI000565Q None [15028112]
  • rs11279109 - APOB XbaI 0.001 [17393087]
  • rs11279109 - SI000565Q 0.05 [17393087]
  • APOB XbaI − SI000565Q 0.006 [17393087]
  • rs11279109 - APOB XbaI - SI000565Q 0.044 [17393087]
  • 3' variable number tandem repeat 3'APOB-VNTR None [9759473]
  • rs693 None [9050915]
  • 3'APOB-VNTR 0.29 [11592926]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 9050915: DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • APOB (9606)
  • APOB (9598)
  • APOB (9615)
  • Apob (10090)
  • Apob (10116)
  • APOB (9031)
  • apob (7955)

  • Inparanoids
  • ENSMUSP00000035761 (10090)
  • ENSRNOP00000039779 (10116)
  • ENSMMUP00000010112 (9544)
  • ENSP00000233242 (9606)



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