Authors: De Benedictis G; Carotenuto L; Carrieri G; De Luca M; Falcone E; Rose G; Yashin AI; Bonafè M; Franceschi C
Abstract: The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10-19 years (3.06 +/- 1.74%) to that aged 40-49 years (8.51 +/- 4.07%). Then it declined reaching the minimum value in centenarians (1.58 +/- 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.Keywords: Adolescent; Adult; Aged; Aged, 80 and over; *Aging; Alleles; Apolipoproteins B/*genetics; Child; Cohort Studies; Cross-Sectional Studies; DNA/analysis; Female; Gene Frequency; Genotype; Humans; Italy; Male; Middle Aged; Minisatellite Repeats/*genetics; Polymerase Chain Reaction/methods
Journal: Annals of human genetics
Issue: Pt 2
Date: Oct. 6, 1998
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De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Yashin AI, Bonafè M, Franceschi C (1998) Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. Annals of human genetics 62: 115-22.