Denigma Buck Institute Health Extension
Polymorphism: VNTR (Variable Number of Tandem Repeats)







Location: 2p24-p23

Factor:
- Symbol: APOB
- Name: apolipoprotein B (including Ag(x) antigen)
- Entrez ID: 338
- Ensembl ID: ENSG00000084674

Factors:
  • APOB apolipoprotein B (including Ag(x) antigen) ( 338 / ENSG00000084674 )


    • Description:

    Significant in females only. For females: P=0.003 vs. whole population; P=0.06 vs all controls; P=0.001 vs. male controls.

    Ethnicity: Italian
    Age of cases: mean age is 102 years
    Shorter lived allele: 35 or more tandem repeats

    Statistics
    - Number of cases/controls: 143 vs 158 (initial)
    - p-value: 0.003 [P = 0.003]
    - Significant: yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR-VNTR (variable number of tandem repeats)

    Reference:
    9050915: DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus.

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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