Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs28362491 NFkB — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    rs708272 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    rs5882 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    S65C HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    56 SNPs - CYP2C gene family CYP2C gene family: CYP2C8, CYP2C9, CYP2C18, CYP2C19 — 1.0 1,384 vs 945 — German Mean age 98.8 — — Candidate Region/Gene 21798861
    rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
    rs3758391 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
    rs1885472 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
    rs2273773 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
    rs10997870 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
    rs2234975 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
    T-455C APOC3 — 0.005 183 vs 110 — Russian 70-106 T C Candidate Region/Gene 11193221
    ACE D/I ACE — 0.02 689 — Danish Minimum age 73 II DI, DD Candidate Region/Gene 12547486
    rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
    ADA genotypes ADA — 0.003 62 vs 64 vs143 vs 272 — Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
    rs1799782 XRCC1 — 0.658 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    rs25487 XRCC1 — 0.51 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    rs861539 XRCC3 — 0.97 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    rs28360135 XRCC4 — 0.29 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    rs507879 CASP5 — 1.4e-05 510 vs 549 — Russian 75–103 AG AA, GG Candidate Region/Gene 20434535
    rs1800629 TNF — 0.019 747 — Italian 19-110 A G Candidate Region/Gene 18511747
    rs1800795 IL-6 — 0.018 285 — Finn 90-95 C G Candidate Region/Gene 15664628
    rs1800871 IL-10 — 0.0026 500 — Japanese 56.7 years; range, 19–100 years TC TT Candidate Region/Gene 16424284
    Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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