Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs3825075 SIRT3 — 1.0 668 — Italian 70+ — — Candidate Region/Gene 23839864
    rs3758391 SIRT1 — 1.0 223 vs 277 — Chinese Average age 93 — — Candidate Region/Gene 23450480
    rs3740051  SIRT1 — 1.0 223 vs 277 — Chinese Average age 93 — — Candidate Region/Gene 23450480
    rs2273773 SIRT1 — 1.0 223 vs 277 — Chinese Average age 93 — — Candidate Region/Gene 23450480
    rs1799990 — — 1.0 150 vs 165 — Polish Centenarian — — Candidate Region/Gene 23406923
    rs4677882 ADCY5 — 0.999 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs1041740 SOD1 — 0.998 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs12876443 FOXO1 1.00 0.989 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.9852 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs9995651 SNCA — 0.98 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs5981072 FOXO4 0.98 0.976 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs11136000 CLU — 0.975 1364 — American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
    rs861539 XRCC3 — 0.97 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    rs3829963 CDKN1A 0.99 0.969 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs8192287 SOD3 — 0.955 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs9470367 CDKN1A 1.01 0.949 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs5189 AGTR1 0.75 0.945 173 vs 376 — Italian 99-106 (mean 100.9±1.7) — — Candidate Region/Gene 22569962
    rs2536512 SOD3 — 0.942 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    mtDNA C150T — — 0.936 556 vs 403 — Chinese 90–108 (94.59±3.34) — — Candidate Region/Gene 21262335
    rs6457931 CDKN1A 1.01 0.936 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs4151702 CDKN1A 1.02 0.93 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs1800591-rs61733139 MTTP — 0.93 164 vs 261 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
    rs12721225 AGTR1 0.37 0.929 173 vs 376 — Italian 99-106 (mean 100.9±1.7) — — Candidate Region/Gene 22569962
    microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 IGF1 — 0.922 493 vs 425 — Chinese (females ≥ 94; males ≥ 90 — — Candidate Region/Gene 20199671
    rs10119 TOMM40 0.94 0.914 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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