Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    Met410Val SHC1 — 0.192 730 563 Human 85+ Met — Candidate Region/Gene 15036421
    rs1333049 — 0.64 0.001 80 (cases) vs 258 healthy young — Human 100–104 C — Candidate Region/Gene 20230275
    rs28940577 MEFV 3.70 0.004 68 vs 196 vs 121 — Human Minimum age 99 G A Candidate Region/Gene 16387839
    APOE e2/e3/e4 APOE 4.40 0.02 179 — Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    rs1800795 IL-6 — 0.018 285 — Finn 90-95 C G Candidate Region/Gene 15664628
    APOE polymorphism APOE — 0.0001 291 vs 589 — Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    APOE e2,e3,e4 APOE — 0.05 185 vs 486 — Finn Over 100 E4 e2 Candidate Region/Gene 8018664
    rs1800587 IL1A — 0.31 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs16944 IL1B — 0.08 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1143634 IL1B — 0.53 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    intron 2 VNTR IL1RN — 0.08 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800795 IL6 — 0.23 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800896 IL10 — 0.64 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800629 TNF — 0.76 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    APOE haplotype - rs1346044 APOE — 0.0001 175 vs 178 — Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    rs429358, rs7412 APOE — 0.001 179 vs 615 — Finn Mean age 100 e4 e2, e3 Candidate Region/Gene 8018664
    rs1061170 CFH 1.78 0.005 491 with follow-up during 4 years — Finn >90 — TT Candidate Region/Gene 19000922
    HRAS1 LASS1 (CCT) APOE — 4.1e-05 147 vs 188 — Georgian — — — Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE — 7.8e-05 147 vs 188 — Georgian — — — Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE — 1e-05 128 vs 115 — Georgian — — — Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE — 9e-06 19 vs 73 — Georgian — — — Candidate Region/Gene 20569235
    rs1887922 IDE 2.02 0.0004 829 vs 1033 — Australian, Caucasian Mixed — — Candidate Region/Gene 18448515
    rs2251101 IDE 1.88 0.0011 829 vs 1033 — Australian, Caucasian Mixed — — Candidate Region/Gene 18448515
    5-HTTLPR SLC6A4 — 0.03 15 male, 53 female centenarians (cases) — Australian, Caucasian 101.0 ± 0.2 L/L (only for males) — Candidate Region/Gene 22985157
    ACE genotype ACE — 0.716 102 vs 7232 — Korean Mean age 102 — — Candidate Region/Gene 12634288

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue