Preliminary evidence of a genetic association between chromosome 9p21.3 and human longevity.

Authors: Emanuele E; Fontana JM; Minoretti P; Geroldi D

Abstract: BACKGROUND: Emerging evidence suggests that there is a significant genetic component to human longevity. One or more genetic variants located on chromosome 9p21.3 and tagged by the single-nucleotide polymorphism (SNP) rs1333049 (G/C) are major risk factors for age-related disorders, including acute myocardial infarction (AMI), stroke, and dementia. We hypothesized that this locus may have widespread effects on aging phenotypes and, as such, influences the ability to achieve a long and healthy life. AIM: The aim of this study was to assess whether the rs1333049 polymorphism is associated with human longevity. METHODS: We tested the rs1333049 polymorphism in a sample of 80 healthy centenarians (39 men and 41 women, aged 100-104), 218 patients younger than 40 who experienced an AMI, and a control group of 258 healthy young volunteers matched to AMI patients for age and sex. RESULTS: The frequency of the C allele of rs1333049 was significantly lower in centenarians compared to young controls, whereas AMI patients showed a higher frequency. After adjustment for gender and traditional vascular risk factors, the C allele of rs1333049 remained significantly associated with a reduced likelihood to reach longevity: Odds ratio (OR) 0.64, 95% confidence interval (CI) 0.39-0.89, p < 0.01. CONCLUSIONS: Our data suggest that the rs1333049 polymorphism at 9p21.3 may influence successful human longevity, possibly by modulating the risk of age-related disorders.

Keywords: Adult; Aged, 80 and over; Case-Control Studies; Chromosomes, Human, Pair 9/*genetics; Female; Gene Frequency/genetics; Genotype; Humans; Longevity/*genetics; Male; Young Adult
Journal: Rejuvenation research
Volume: 13
Issue: 1
Pages: 23-6
Date: March 17, 2010
PMID: 20230275
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Emanuele E, Fontana JM, Minoretti P, Geroldi D (2010) Preliminary evidence of a genetic association between chromosome 9p21.3 and human longevity. Rejuvenation research 13: 23-6.

Longevity Variant Associations (p-value):
  • rs1333049 (0.001)

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