Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (22)   No Age Effect (17)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (28)   Haplotype (1)  
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4537545 IL6R — 3e-18 308 — American, European, Ashkenazi Jewish 75.7 — — Candidate Region/Gene 19249341
    HRAS1 LASS1 (CGT) APOE — 1.06e-09 68 vs 68 — American — — — Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE — 6.91e-07 204 vs 251 — American — — — Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE — 1e-06 79 vs 88 — American — — — Candidate Region/Gene 20569235
    rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 — GTCT Candidate Region/Gene 22340368
    HRAS1 LASS1 (CCT) APOE — 9.5e-05 204 vs 251 — American — — — Candidate Region/Gene 20569235
    rs429358, rs7412 APOE — 0.0005 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 e4 e2 Candidate Region/Gene 18034366
    rs2075650 APOE — 0.000527 1364 — American, British Age range 50-108; mean age at death 80.2 C T Candidate Region/Gene 22445811
    HRAS1 LASS1 (CCT) APOE — 0.00197 125 vs 163 — American — — — Candidate Region/Gene 20569235
    rs2075650 TOMM40 0.70 0.002 2307 vs 764 — American, Danish Mean age 60.2 G A Candidate Region/Gene 23040522
    −438 G/A TAFI 0.53 0.003 2224 — American, Caucasian 65+ G (men) — Candidate Region/Gene 15939070
    apoE haplotypes — — 0.0042 3924 — American 5-70 Apo e4 — Candidate Region/Gene 21332925
    rs429358, rs7412 APOE 0.75 0.005 2307 vs 764 — American, Danish Mean age 60.2 e4 e2 Candidate Region/Gene 23040522
    rs508641 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs915179 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs9282861 SULT1A1 — 0.017 68 vs 49 — American, Caucasian 70-99 — GG Candidate Region/Gene 9854023
    rs3814314 LMNA — 0.017 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs2866164 MTP — 0.024 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 GG — Candidate Region/Gene 18034366
    −675 4G/5G PAI1 0.81 0.04 2224 — American, Caucasian 65+ 5G (men) — Candidate Region/Gene 15939070
    rs6669212 LMNA — 0.041 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs5882 CETP 1.30 0.041 318 vs 350 376 vs 506 American, Caucasian Mean age 100.8 non-GG GG Candidate Region/Gene 18034366
    HRAS1 LASS1 (CCT) APOE — 0.0511 68 vs 68 — American — — — Candidate Region/Gene 20569235
    rs1468772 LMNA 1.17 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs582690 LMNA — 0.078 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs547915 LMNA — 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
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    • 25 of 46 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue