Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (84)   No Age Effect (161)  
  • Study type: + -
    ‑ (14)   Candidate Region/Gene (180)   Genome‑Wide Association Study (67)   Mitochondrial Haplogroup (1)  
  • Variant type: + -
    SNP (157)   Haplotype (23)   Other (1)   STR (1)   Deletion (1)   VNTR (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2229765 IGF-1 — 0.04 222 vs 288 — Italian >85 G A Candidate Region/Gene 19460140
    rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs28969505 YTHDF2 — 0.047 136 vs 275 — Italian Mean age 101 — 15-15 (205 bp) Candidate Region/Gene 16799135
    rs2802288 FOXO3A 1.51 0.003 281 vs 195 — Italian 90–108 G A Candidate Region/Gene 19415983
    CHIT1 24-bp duplication CHIT1 — 0.05 129 vs 129 29 versus 129 Tunisian, Greek, Italian Mean age 97.6 Absence of duplication Presence of duplication Candidate Region/Gene 19881466
    ASP299GLY TLR4 — 0.04 8 vs 8 — Italian 25-50 — — — 16803999
    HUMTHO1 (STR) THO — 0.05 196 (143 f, 53 m) vs 358 (296 f; 64 m) — Italian >100 9-10 (long alleles, homozygous genotype) — Candidate Region/Gene 9887369
    Not specified REN — 0.029 157 vs 218 — Italian Centenarians 11 — Candidate Region/Gene 15105583
    APOA1-MspI-RFLP A/P alleles APOA1 — 0.045 413 vs. 571 — Italian median age 101 A P Candidate Region/Gene 12556235
    HinfI347 APOA4 — 0.05 71 vs 100 — Italian mean102.3 years — — Candidate Region/Gene 9622284
    rs675 APOA4 — 0.05 58 vs 100 — Italian Mean age 102,3 — A (NCBI) Candidate Region/Gene 9622284
    VNTR (Variable Number of Tandem Repeats) APOB — 0.003 143 vs 158 — Italian mean age is 102 years 35 or more tandem repeats — Candidate Region/Gene 9050915
    S61712.1 (GenBank, 3` VNTR) — — 0.003 143 (51 m, 92 f) vs 158 (77 m, 81 f) — Italian 102 +/- 2 <35 repeats — Candidate Region/Gene 9050915
    GSTT1 deletion GSTT1 — 0.03 94 vs 418 — Italian Mean age 100.2 Not homozygous for d Homozygous for delet Candidate Region/Gene 11162685
    - GSTM1 — 0.74 94 vs 418 — Italian 100 years vs 46 years — — - 11162685
    - CYP1A — 0.68 94 vs 418 — Italian 100 years vs 46 years — — Candidate Region/Gene 11162685
    (A/C)−110 HSP70-1 0.40 0.005 120 vs 471 — Italian 100 years and above A — Candidate Region/Gene 14501185
    rs2430561 IFNG — 0.02 174 vs 248 — Italian >99 T (females) — Candidate Region/Gene 11772518
    rs2229765 IGF1R — 0.03 218 vs 278 — Italian 98 — AA or AG Candidate Region/Gene 12843179
    −1082 G/A IL10 — 0.025 190 vs 260 — Italian >99 years old — G Candidate Region/Gene 11857058
    rs1800471 TGFB1 — 0.034 172 vs 247 — Italian 90-103 GC (genotype) — Candidate Region/Gene 15569360
    rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young — Italian 91+ (very old), 73-91 (old) G C Candidate Region/Gene 23125046
    rs1042522 TP53 — 0.006 503 vs 569 — Italian >81 R — Candidate Region/Gene 23125046
    • Page 1 of 11
    • 25 of 263 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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