Authors: Albani D; Batelli S; Polito L; Vittori A; Pesaresi M; Gajo GB; De Angeli S; Zanardo A; Gallucci M; Forloni G
Abstract: BACKGROUND: An attenuation of the insulin-like growth factor 1 (IGF-1) signaling has been associated with elongation of the lifespan in simple metazoan organisms and in rodents. In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (IGF-1R). METHODS: In an elderly population from North-eastern Italy (n = 668 subjects, age range 70-106 years) we investigated the IGF-1R polymorphism G3174A (rs2229765) and the plasma concentration of free IGF-1. Frequency distributions were compared using chi2-test "Goodness of Fit" test, and means were compared by one-way analysis of variance (ANOVA); multiple regression analysis was performed using JMP7 for SAS software (SAS Institute, USA). The limit of significance for genetic and biochemical comparison was set at alpha = 0.05. RESULTS: Males showed an age-related increase in the A-allele of rs2229765 and a change in the plasma level of IGF-1, which dropped significantly after 85 years of age (85+ group). In the male 85+ group, A/A homozygous subjects had the lowest plasma IGF-1 level. We found no clear correlation between rs2229765 genotype and IGF-1 in the females. CONCLUSION: These findings confirm the importance of the rs2229765 minor allele as a genetic predisposing factor for longevity in Italy where a sex-specific pattern for IGF-1 attenuation with ageing was found.Keywords: Aged; Aged, 80 and over; Aging/blood/genetics; Alleles; Female; Humans; Insulin-Like Growth Factor I/*genetics/*metabolism; Italy; Longevity/*genetics; Male; Polymorphism, Genetic/*genetics; Questionnaires; Receptor, IGF Type 1/*blood/*genetics; Sex Factors
Journal: BMC geriatrics
Date: May 23, 2009
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Albani D, Batelli S, Polito L, Vittori A, Pesaresi M, Gajo GB, De Angeli S, Zanardo A, Gallucci M, Forloni G (2009) A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study. BMC geriatrics 9: 19.