Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
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  • Variant type: + -
    SNP (209)   Haplotype (17)   Other (1)   STR (7)   Deletion (1)  
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs11136000 CLU — 0.975 1364 — American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
    rs11767557 EPHA1 — 0.267 1364 — American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    rs1485780 CD2AP — 0.604 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs1801274 FCGR2A — 1.0 408 vs 446 vs 454 — German Centenarians — — Candidate Region/Gene 16893392
    rs3764650 ABCA7 — 0.135 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs3818361 CR1 — 0.563 1364 — American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    rs3851179 PICALM — 0.227 1364 — American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    rs3865444 CD33 — 0.442 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs610932 MS4A6A — 0.176 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs744373 BIN1 — 0.689 1364 — American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
    SLC6A4 SLC6A4 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    (HLA)-A1, B8, DR3 — — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
    - GSTM1 — 0.54 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    - PARP1 — 1.0 239 vs 198 — French >100 — — Candidate Region/Gene 9587069
    -1377G/A FAS — 0.106 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
    -330T/G IL2 1.43 0.096 168 vs 214 — Italian >99 — — Candidate Region/Gene 16518704
    -351A/G ESR1 — 0.05 148 vs 414 — Polish 99.6-107.2; mean= 101.1±1.2 — — Candidate Region/Gene 20599431
    -397T/C ESR1 — 0.06 149 vs 414 — Polish 99.6-107.2; mean= 101.1±1.3 — — Candidate Region/Gene 20599431
    -670A/G FAS — 0.608 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
    11 different snps tested, not all given. MTTP — 1.0 1398 vs 777 — British 77.9 ± 0.2 — — Candidate Region/Gene 17339647
    16 bp duplication in intron 3 (WT=no duplicaiton) TP53 — 0.59 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
    3'APOB-VNTR APOB — 0.29 175 vs 200 — Danish >100 — — Candidate Region/Gene 11592926
    5178 adenine/cytosine ND2 — 0.363 95 vs 298 — Chinese 76.2±5.0 C — Candidate Region/Gene 12384792
    ACE genotype ACE — 0.716 102 vs 7232 — Korean Mean age 102 — — Candidate Region/Gene 12634288
    AGT AGT — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    • Page 1 of 16
    • 25 of 382 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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