Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1037381 — — 3.99e-05 1364 — American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs6491207 — — 4.63e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    J mtDNA haplogroup — — 0.027 138 vs 138 — Spaniard >85 (oldest age group) — — — 18931934
    8899A — — 0.0016 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    152C — — 0.004 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    73G — — 0.0086 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    rs2149954 — 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
    rs1525501 — 0.72 4.94e-06 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs3803833 — 0.77 2.72e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1016013 — 1.21 2.87e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1822590 — 1.21 7.57e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1456669 — 0.78 9.89e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs11218921 — 0.59 5.47e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1525501 — 0.81 8.97e-05 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs1456669 — 0.82 0.000312 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs1879417 — — 0.018 321 vs 442 — Italian 89-107 — — Candidate Region/Gene 23572278
    rs2701858, rs9486902 — 3.23 0.0001 1088 — Danish 92+ — — Candidate Region/Gene 23607278
    C4L*Q0 — — 0.003 700 vs 900 — German 94+ — — Candidate Region/Gene 24465950
    rs7843014 — 0.37 0.001 175 vs 355 — Spanish 100-111 A C Candidate Region/Gene 24930376
    rs4673 — 1.48 0.022 — — Russian — C T Candidate Region/Gene 23755540
    rs1800624 — — 0.028 28 vs 56 — Caucasian 90+ non-AA AA Candidate Region/Gene 24284407
    rs10014396 SNCA — 0.021 769 total (see notes) — Caucasian >90 (oldest age group) C — Candidate Region/Gene 22912757
    rs3775439 SNCA — 0.025 769 total (see notes) — Caucasian >90 (oldest age group) A — Candidate Region/Gene 22912757
    APOE e2/e3/e4 APOE 4.40 0.02 179 — Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    rs429358 + rs7412 APOE — 0.04 1236 vs 326 — Chinese 60+ e4 non-e4 Candidate Region/Gene 9792194

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue