Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (1)   Candidate Region/Gene (153)   Meta‑Analysis (30)   Genome‑Wide Association Study (50)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP « 
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs11218921 — 0.59 5.47e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs2738173 DEFB1 0.78 0.00016 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950
    rs1525501 — 0.81 8.97e-05 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs1456669 — 0.82 0.000312 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs4729049 CDK6 1.21 0.001311 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs11954180 SLC6A7 1.30 0.001639 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs2596230 RYR3 2.61 0.000383 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs1800392 WRN 0.79 0.000708 2715 vs 2725 — Multiethnic 100 — — Meta-Analysis 24244950
    rs1333049 CDKN2B-AS1 — 0.088 152 vs 343 — Spanish 100 C G Candidate Region/Gene 24163049
    rs7799039 LEP — 0.048 128 vs 414 — Polish 100+ — GG Candidate Region/Gene 24549597
    rs1137100 LEPR — 0.026 128 vs 414 — Polish 100+ AA — Candidate Region/Gene 24549597
    rs1799945 HFE — 0.008 57 vs 60 — Italian 100-105 — — Candidate Region/Gene 12714263
    rs7843014 — 0.37 0.001 175 vs 355 — Spanish 100-111 A C Candidate Region/Gene 24930376
    rs7460 PTK2 0.40 0.001 175 vs 355 — Spanish 100-111 A T Candidate Region/Gene 24930376
    rs429358, rs7412 APOE — 0.009 1477 total — Italian 18-109 e4 non-e4 - 16896546
    rs1008438 HSPA1A — 0.009 894 total — Italian 18-109 A C Candidate Region/Gene 16896546
    rs1008438 HSPA1A — 0.02 894 total — Italian 18-109 C A (applies to males) Candidate Region/Gene 16896546
    rs1800775 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years CC non-CC Candidate Region/Gene 23083790
    rs708272 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years GG non-GG Candidate Region/Gene 23083790
    rs9330200 TUBB4B — 6e-53 5036 — American 28-70 AA, AT TT Genome-Wide Association Study 22174011
    rs2292664 RIMBP2 — 1.4e-37 5036 — American 28-70 CC, CG GG Genome-Wide Association Study 22174011
    rs5491 ICAM1 — 5e-66 5036 — American 28-70 TT, AT AA Genome-Wide Association Study 22174011
    rs12778366 SIRT1 0.69 0.025 1390 — Dutch 36 to 79 — — Candidate Region/Gene 23505545
    rs1800795 IL6 — 0.01 1710 total — Danish 47-100 C G Candidate Region/Gene 15130757
    rs3758391 SIRT1 1.45 0.026 246 vs 236 — Chinese 60-90 — C Candidate Region/Gene 20633545

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue