Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (39)   No Age Effect (43)  
  • Study type: + -
    ‑ (1)   Candidate Region/Gene (53)   Meta‑Analysis (1)   Complete Mitochondrial Genome (1)   Mitochondrial Haplogroup (31)  
  • Variant type: + -
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    9bp-deletion,10873T mtDNA — 0.311 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    8584A,9bp-deletion,10873T mtDNA — 0.117 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    15235G,8584A,9bp-deletion,10873T mtDNA — 0.086 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    15662G,8584A,9bp-deletion,10873T mtDNA — 0.357 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    5465C,9bp-deletion,10873T mtDNA — 0.105 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    13590A,9bp-deletion,10873T mtDNA — 0.43 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    D4a mtDNA haplogroups — 0.05 112 vs 96 — Japanese Minimum age 105 non-D4a D4a Complete Mitochondrial Genome 18545700
    rs1800591-rs61733139 MTTP — 0.46 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90+ apoE4 — Candidate Region/Gene 11780357
    APOE polymorphism APOE 3.26 0.001 64 vs 1344 — Italian 100+ e4 e2 Candidate Region/Gene 16960022
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 — Italian 100+ — REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 — GTCT Candidate Region/Gene 22340368
    LPA isoform LPA — 0.05 84 (cases) vs 517 — Japanese 80+ Lp(a)F, Lp(a)B — Candidate Region/Gene 11269751
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
    Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
    APOE polymorphism APOE — 0.0001 291 vs 589 — Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    rs1800896 - rs1800629 IL10 — 0.038 174 vs 224 — Italian >100 — GG-GG (only in men) Candidate Region/Gene 12676903
    rs1800591-rs61733139 MTTP — 0.61 197 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
    HP 1/2 HP 1.27 0.0194 1072 total — Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
    HP*1 F/S HP 0.82 0.33 1072 total — Italian >88 — — Candidate Region/Gene 21147083
    rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    APOE haplotype - rs1346044 APOE — 0.0001 175 vs 178 — Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 — Italian >88 e4 e2 Candidate Region/Gene 21703254
    APOE polymorphism APOE — 0.437 1408 cases — Brazilian 69.3 +/- 7.2 — — Candidate Region/Gene 17934638

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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