Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs3814314 LMNA — 0.017 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs11578696 LMNA — 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) Mean age 101.5 — — Candidate Region/Gene 22340368
    rs4661146 LMNA — 0.12 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs10737170 LMNA — 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs915179 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs2485662 LMNA — 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) Mean age 101.5 — — Candidate Region/Gene 22340368
    rs547915 LMNA — 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs582690 LMNA — 0.078 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs6686943 LMNA — 0.51 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs508641 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs12117552 LMNA — 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs4641 LMNA — 0.5 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs12063072 LMNA — 0.36 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs1468772 LMNA 1.17 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs6669212 LMNA — 0.041 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs2275075 LMNA — 0.54 873 vs 443 New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K — Candidate Region/Gene 23354683
    rs275653 AGTR1 3.57 0.007 173 vs 376 598 vs 422 Italian 99-106 (mean 100.9±1.7) A G Candidate Region/Gene 22569962
    rs740746 ADRB1 — 0.556 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs1042718 ADRB2 1.27 0.014 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 C A Candidate Region/Gene 23020224
    rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224
    rs2053044 ADRB2 — 0.138 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs1042713 ADRB2 — 0.149 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs1042714 ADRB2 — 0.558 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs2877709 ADCY5 — 0.767 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    • Page 1 of 15
    • 25 of 375 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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