Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (31)   No Age Effect (17)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    Haplotype « 
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    e4 APOE — 0.04 376 vs 376 — Canadian 85+ e4 — Candidate Region/Gene 24126160
    e4 APOE 0.55 0.03 163 vs 1039 — Spanish 100+ e4 — Candidate Region/Gene 24534555
    e4 APOE 0.41 0.05 79 vs 597 — Italian 100+ e4 — Candidate Region/Gene 24534555
    e4 APOE 0.35 0.001 729 vs 498 — Japanese 100+ e4 — Candidate Region/Gene 24534555
    rs1042718-rs1042719 ADRB2 0.63 1.86e-05 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G-C A-C Candidate Region/Gene 23020224
    rs2107538-rs2280789 RANTES — 0.04 104 vs 110 — Spaniard Mean age 89.6 non G-C haplotypes G-C Candidate Region/Gene 22265023
    rs2107538-rs2280789 RANTES 4.90 0.03 104 vs 110 — Spaniard Mean age 89.6 non A-T haplotypes A-T Candidate Region/Gene 22265023
    rs1544410-rs17878969 VDR 15.30 0.001 104 vs 114 — Caucasian, Spaniard >85 non G-S haplotypes G-S Candidate Region/Gene 20407924
    rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 VDR 11.50 0.024 104 vs 114 — Caucasian, Spaniard >85 G-G-C-G-S non G-G-C-G-S haplotypes Candidate Region/Gene 20407924
    rs699947-(−1190G/A)-rs1570360-(−634G/C) VEGFA — 0.03 — 332 vs 648 Italian 85-99 (mean 89.8±2.8) non A-A-G-G haplotypes A-A-G-G Candidate Region/Gene 17574707
    rs1800796-(−373(A)n(T)m)-rs1800795 IL6 — 0.07 1710 total — Danish 47-100 G-(−373(A)8(T)12)-C non G-(−373(A)8(T)12)-C haplotypes Candidate Region/Gene 15130757
    rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
    rs1061581-rs1043618-rs2227956 — 4.51 0.016 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
    HP 1/2 HP 1.27 0.0194 1072 total — Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
    HP*1 F/S HP 0.82 0.33 1072 total — Italian >88 — — Candidate Region/Gene 21147083
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.03972 184 vs 184 — Italian 100 A-G-G-A non A-G-G-A haplotypes Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.9852 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1761 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1282 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.00394 184 vs 184 — Italian 100 non G-G-G-C haplotypes G-G-G-C Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.02249 184 vs 184 — Italian 100 A-G-G-A-T-A non A-G-G-A-T-A haplotypes Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.8 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.1856 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.139 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.00211 184 vs 184 — Italian 100 non G-G-G-C-C-G haplotypes G-G-G-C-C-G Candidate Region/Gene 20126416
    • Page 1 of 3
    • 25 of 53 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue