Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (39)   No Age Effect (43)  
  • Study type: + -
    ‑ (1)   Candidate Region/Gene (53)   Meta‑Analysis (1)   Complete Mitochondrial Genome (1)   Mitochondrial Haplogroup (31)  
  • Variant type: + -
    Haplotype « 
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    1736G,10873T mtDNA — 0.288 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.1856 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1761 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    7600A,4833G,14569A,10400T mtDNA — 0.153 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    3970T,12705C,10873T mtDNA — 0.147 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    3010A,5178A,10400T mtDNA — 0.141 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.139 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1282 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    8584A,9bp-deletion,10873T mtDNA — 0.117 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    5465C,9bp-deletion,10873T mtDNA — 0.105 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    15235G,8584A,9bp-deletion,10873T mtDNA — 0.086 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1800796-(−373(A)n(T)m)-rs1800795 IL6 — 0.07 1710 total — Danish 47-100 G-(−373(A)8(T)12)-C non G-(−373(A)8(T)12)-C haplotypes Candidate Region/Gene 15130757
    12358G,5417A,10873T mtDNA — 0.058 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    LPA isoform LPA — 0.05 84 (cases) vs 517 — Japanese 80+ Lp(a)F, Lp(a)B — Candidate Region/Gene 11269751
    D4a mtDNA haplogroups — 0.05 112 vs 96 — Japanese Minimum age 105 non-D4a D4a Complete Mitochondrial Genome 18545700
    Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
    rs11279109 - SI000565Q APOB — 0.05 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - S D - M Candidate Region/Gene 17393087
    HP1/2 common polymorphism HP — 0.05 200 (cases) vs 539 (initial) (initial) — Italian >88 — — Candidate Region/Gene 21703254
    C4B1 C4B — 0.05 77 (cases) vs 235 — Italian Mean age 101 — — Candidate Region/Gene 10219002
    e4 APOE 0.41 0.05 79 vs 597 — Italian 100+ e4 — Candidate Region/Gene 24534555
    rs11279109 - APOB XbaI - SI000565Q APOB — 0.044 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
    rs2107538-rs2280789 RANTES — 0.04 104 vs 110 — Spaniard Mean age 89.6 non G-C haplotypes G-C Candidate Region/Gene 22265023
    e4 APOE — 0.04 376 vs 376 — Canadian 85+ e4 — Candidate Region/Gene 24126160
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.03972 184 vs 184 — Italian 100 A-G-G-A non A-G-G-A haplotypes Candidate Region/Gene 20126416

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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