Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (40)   No Age Effect (60)  
  • Study type: + -
    ‑ (3)   Candidate Region/Gene (70)   Complete Mitochondrial Genome (1)   Mitochondrial Haplogroup (30)  
  • Variant type: + -
    SNP (31)   Locus (2)   Haplotype (40)   STR (5)   Deletion (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224
    C150T mtDNA L2 — 1.0 556 vs. 403 — Chinese 90-108 — — Mitochondrial Haplogroup 21262335
    rs2288377 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
    rs5742612 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
    rs35767 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
    rs17630266 FOXO1 — 1.0 761 vs 1056 350 vs 350 Chinese mean age 102.3 — — Candidate Region/Gene 19793722
    rs3758391 SIRT1 — 1.0 223 vs 277 — Chinese Average age 93 — — Candidate Region/Gene 23450480
    rs3740051  SIRT1 — 1.0 223 vs 277 — Chinese Average age 93 — — Candidate Region/Gene 23450480
    rs2273773 SIRT1 — 1.0 223 vs 277 — Chinese Average age 93 — — Candidate Region/Gene 23450480
    rs4677882 ADCY5 — 0.999 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    9824C,10400T mtDNA — 0.955 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    4833G,14569A,10400T mtDNA — 0.949 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    mtDNA C150T — — 0.936 556 vs 403 — Chinese 90–108 (94.59±3.34) — — Candidate Region/Gene 21262335
    microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 IGF1 — 0.922 493 vs 425 — Chinese (females ≥ 94; males ≥ 90 — — Candidate Region/Gene 20199671
    rs9844212 ADCY5 — 0.901 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    MTP -493G/T MTP — 0.854 — — Chinese — — — - 23273182
    rs4646994 ACE — 0.849 399 vs 302 — Chinese >90 years — — Candidate Region/Gene 19502260
    7196A,10400T mtDNA — 0.847 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    14569A,10400T mtDNA — 0.796 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    14979C,3010A,5178A,10400T mtDNA — 0.781 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs2877709 ADCY5 — 0.767 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    10646A,10400T mtDNA — 0.753 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    12811C,9824C,10400T mtDNA — 0.587 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    1107C,5178A,10400T mtDNA — 0.559 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1042714 ADRB2 — 0.558 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    • Page 1 of 5
    • 25 of 104 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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