Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (243)   No Age Effect (314)  
  • Study type: + -
    GWAS (2)   ‑ (1)   Candidate Region/Gene (375)   Meta‑Analysis (37)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (147)   Mitochondrial Haplogroup (1)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP « 
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1805097 IRS2 2.07 0.04 144 vs 418 — Caucasian 85 to 104, mean age = 96 ± 4 C — Candidate Region/Gene 19887537
    rs964403 SUMF1 2.07 4.91e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs3864051 SUMF1 2.07 5.49e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4505466 SH3BP4 2.06 8.31e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4777170 — 2.00 4.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs3211994 NTLH1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs3211994 NTHL1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) G — Candidate Region/Gene 22406557
    rs2277472 MAMDC1 1.95 7.93e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs73598374 ADA 1.94 0.036 261 vs 144 — Italian 66-88 G*/G* A*+ Candidate Region/Gene 21865054
    rs846427 — 1.94 3.82e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4594173 MADMC1 1.94 9.81e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7915479 CDH23 1.92 2.81e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs6769400 — 1.91 1.99e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4938180 IGSF4 1.91 2.16e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4646 CYP19 1.90 0.04 108 vs 85 — Italian 90+ — T Candidate Region/Gene 20819792
    rs1582594 — 1.87 4.76e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs189037 ATM 1.85 0.037 67 vs 61 — Italian Centenarians — — Candidate Region/Gene 22960875
    rs10513702 — 1.85 4.53e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1428689 — 1.85 5.51e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs13251813 WRN 1.84 0.0002 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs6701445 TAF5L 1.84 4.19e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs2967137 — 1.83 4.64e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs3102484 — 1.82 9.2e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4291539 — 1.81 4.41e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs17702471 GPC6 1.81 8.33e-05 2202 vs 2164 — Caucasian 100 — — Meta-Analysis 24244950

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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