Longevity Variant Database

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs440446 APOE 1083.00 0.509 597 vs 1275 Sichuan 90+ Candidate Region/Gene 24924924
    rs1544410-rs17878969 VDR 15.30 0.001 104 vs 114 Caucasian, Spaniard >85 non G-S haplotypes G-S Candidate Region/Gene 20407924
    rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 VDR 11.50 0.024 104 vs 114 Caucasian, Spaniard >85 G-G-C-G-S non G-G-C-G-S haplotypes Candidate Region/Gene 20407924
    APOE e2,e3,e4 APOE 9.24 0.01 224 vs 441 Ashkenazi Jewish 75 e4 e2 Candidate Region/Gene 15621215
    rs2280789 RANTES 8.80 0.03 104 vs 110 Spaniard Mean age 89.5 C T Candidate Region/Gene 22265023
    –11391 G/A ADIPOQ10 8.48 0.026 148 vs 414 Polish Mean age 101.1 +/- 1.2 G A Candidate Region/Gene 23339001
    mtDNA haplogroups mtDNA 7.56 0.0015 74 vs 187 Amish >80 years non-X X Mitochondrial Haplogroup 21750925
    1376G/T;1388G/A;95A/G;871G/A;1024C/T;1360C/T;392 G/T G6PD 6.30 0.013 173 total (see notes) Chinese >80 Candidate Region/Gene 17077204
    rs1801133 MTHFR 6.00 0.014 224 vs 441 Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
    KL-VS KLOTHO 5.88 0.004 216 vs 309 Ashkenazi Jewish 95 years and over homozygous Candidate Region/Gene 15677572
    rs969845 5.87 7.22e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs327519 PAX4 (for males) 5.70 0.004 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs327512 5.55 0.005 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs2107538-rs2280789 RANTES 4.90 0.03 104 vs 110 Spaniard Mean age 89.6 non A-T haplotypes A-T Candidate Region/Gene 22265023
    rs1061581-rs1043618-rs2227956 4.51 0.016 191 vs 53 Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
    APOE e2/e3/e4 APOE 4.40 0.02 179 Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    rs6166 FSHR 4.21 0.036 114 vs 173 Italian >/=90 Asn Ser Candidate Region/Gene 22985084
    rs2072454, rs2293347, rs3807362, rs884225 EGFR (for females) 4.11 0.003 137 vs 213 Korean Mean age 90 CGCA Genome-Wide Association Study 19641380
    rs1008438 HSPA1A 3.86 0.016 168 cases Danish Mean age 92.8 +/- 0.4 А Candidate Region/Gene 20388090
    rs1450740, rs1450741, rs1562818, rs1980042, rs1027989, rs 1546518, rs3968371 3.72 0.002 137 vs 213 Korean Mean age 90 CTCCGCA Genome-Wide Association Study 19641380
    rs2838810 ADARB1 3.71 0.0136 877 vs 1808 Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. Northern European 96–119 (median: 103) AA/AG 20011587
    rs28940577 MEFV 3.70 0.004 68 vs 196 vs 121 Human Minimum age 99 G A Candidate Region/Gene 16387839
    rs422858 AGTR1 3.57 0.007 173 vs 376 Italian 99-106 (mean 100.9±1.7) AG CC Candidate Region/Gene 22569962
    rs275653 AGTR1 3.57 0.007 173 vs 376 598 vs 422 Italian 99-106 (mean 100.9±1.7) A G Candidate Region/Gene 22569962
    rs5882 CETP 3.56 0.001 213 vs 258 Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
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    • 25 of 1635 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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